Why Testing How To Response Resources
Why This Matters

Counterfeit "prescription" pills and unexpected adulterants (like fentanyl and xylazine) are widespread. Fentanyl is a potent synthetic opioid that has driven large increases in overdose deaths. Xylazine ("tranq") is a non-opioid veterinary sedative that does not respond to naloxone and increases risk of severe wounds and prolonged sedation. Treat unknown pills as potentially lethal.

Sources: CDC — Fentanyl Testing Guidance, CDC — Xylazine, MN Dept of Health — Drug Overdose Prevention.

Testing — What Works & What Doesn't

Fentanyl Test Strips (FTS)

FTS are a fast, low-cost tool to check for fentanyl in pills, powders, or residue. They can lower risk by informing choices — but they are not perfect.

  • Follow manufacturer instructions exactly (sample size, dilution). Improper use is a common cause of false results.
  • FTS can miss some fentanyl analogs depending on strip sensitivity and sample concentration — a negative result is not a guarantee of safety.
  • FTS do not detect xylazine; xylazine test strips (XTS) exist but are newer and not yet as widely distributed.

Authoritative info: CDC — What You Can Do to Test for Fentanyl and SAMHSA — Fentanyl & Xylazine Test Strips.

Reagent Kits & FTIR

Reagent color tests (Marquis, Mecke, Mandelin) can indicate some drug classes (MDMA, some opioids, certain stimulants) but cannot reliably detect fentanyl and can be fooled by carefully pressed counterfeits. Use reagents as one tool — not the only tool.

FTIR / laboratory & event-based checking (spectrometers) identify a broader range of substances and are the most informative option when available. Many harm-reduction programs and some festivals offer FTIR or GC-MS testing events.

Source: DanceSafe — testing resources & reagent supplies, SAMHSA Overdose Prevention & Response Toolkit (PDF).

How To Test — Practical Steps
  1. Prepare a clean surface & tools. Use a sterile container, clean utensil, and fresh water for dissolving samples.
  2. Take only a tiny sample. For pills: scrape a very small corner (do not consume the scraped powder). For powders: use a pea-size amount.
  3. Use FTS first (if available): dissolve the tiny sample in water exactly per strip instructions and apply the strip. Wait the specified time before reading.
  4. If available, get FTIR testing. If an FTIR or lab service is available (SSP, event testing, safe recovery sites), submit the sample for a more complete reading.
  5. Remember limitations: Negative FTS does not equal safe; reagent tests don't detect fentanyl reliably; xylazine requires separate testing.
If you don't have reliable testing: Do not assume safety. Consider not using the substance. If someone chooses to use, use a very small test dose, do not use alone, avoid mixing depressants (alcohol, benzodiazepines), and have naloxone and a sober person present.
Visual Cues — Helpful But Not Definitive

Counterfeiters often copy shapes, logos, and coatings. Visual checks can sometimes catch obvious fakes (misprinted logos, off colors, uneven edges), but modern counterfeits are frequently indistinguishable from authentic pills. Always test.

Pill/TypePossible Red FlagsWhy Visuals Aren't Enough
M30 oxycodoneOff-color shade, fuzzy or incorrect imprint, uneven edgesPressing techniques can reproduce imprints & coatings — testing required.
"Xanax" barsCrumbling, wrong score, wrong spacing in imprintFake bars are often visually convincing — may contain fentanyl or other sedatives.
"Adderall" / stimulantsOdd taste, unusual dust, inconsistent capsule contentsStimulant counterfeits may contain meth, fentanyl, or other adulterants.
Overdose Response — Quick Checklist
  1. Call 911 immediately. Tell dispatch: "Suspected overdose; not breathing" and give the location.
  2. Give naloxone (Narcan) if available. Nasal or injectable naloxone reverses opioid effects (including fentanyl) and should be given right away.
  3. Start rescue breathing or CPR if the person is not breathing or has inadequate breathing.
  4. Place in recovery position (on their side) if they are breathing after naloxone, and stay until EMS arrives.
  5. Give additional naloxone doses every 2–3 minutes if there is no response, and continue until help arrives.

Legal protections: Minnesota's Good Samaritan / overdose immunity laws protect callers from certain drug possession charges when they call for medical assistance during an overdose. See Minnesota statute: Minn. Stat. §604A.05.

Sources: SAMHSA Overdose Prevention & Response Toolkit (PDF, 2025), CDC testing guidance.

Verified Resources — Minnesota & National

Below are trusted organizations, guides, and programs you can link to or contact. All links go to official resource pages.

SAMHSA — Overdose Prevention & Response Toolkit (2025)

Comprehensive, up-to-date guidance for preventing & responding to overdose. PDF guide for peers, programs, clinicians.

Open SAMHSA PDF

Minnesota Dept. of Health — Overdose & Opioids

State dashboards, harm reduction program info, xylazine resources.

MN Dept. of Health

Steve Rummler HOPE Network (MN)

Statewide Naloxone Access Points, mail naloxone, trainings, and FTS distribution.

Steve Rummler HOPE Network

Minnesota DHS — Safe Recovery Sites

State program information and implementation updates for safer recovery sites and supervised services.

MN DHS — Safe Recovery Sites

DanceSafe — Test Strips & Reagent Supplies

Reagent color charts, FTS, and testing supplies for peer programs and individuals.

DanceSafe Shop & Resources

Never Use Alone (Remote Spotting)

Peer-run line to stay on the phone with someone while they use and call for help if needed.

NeverUseAlone.com

CDC — Fentanyl & Xylazine Info

Practical guidance on testing, xylazine harms, and public health alerts.

CDC — Testing & Safety

Harm Reduction Coalition — Resource Center

Training materials, policy guides, and technical assistance for programs.

Harm Reduction Coalition
Downloadable, Verified Guides
Practical Harm-Reduction Tips
  • Carry naloxone every time. In Minnesota, naloxone is available through pharmacies and statewide programs.
  • Start low & go slow. If you choose to use, test a tiny amount first and wait at least 30–60 minutes before considering more.
  • Don't mix depressants. Opioids + benzodiazepines or alcohol greatly increase overdose risk.
  • Don't use alone. Use with a trusted person or a service like Never Use Alone.
  • Watch for wounds with xylazine exposure — xylazine can cause severe skin ulcers; seek wound care early.
Final Words — Short And Important

No pill is worth your life. Test what you can, carry naloxone, never use alone, and call 911 if someone is overdosing. If you want, PLURderapolis can print pocket cards or run trainings at your booth — get in touch through our contact page.

Disclaimer: This page is harm-reduction and educational. We do not encourage illegal drug use. If you are in a medical emergency, call 911. For treatment referrals, see SAMHSA's national helpline at 1-800-662-HELP (4357) or visit FindTreatment.gov.