💊 SSRI / SNRI + Party Drugs
(Lexapro, Zoloft, Prozac, Effexor, Cymbalta)
- + MDMA / Molly: Dulls the high → redosing → serotonin syndrome.
- + LSD / Shrooms: Flat visuals or erratic tripping. Tempts unsafe stacking.
- + Cocaine / Adderall: Anxiety spike, heart risk, mood crashes.
💥 Wellbutrin + Stimulants
- + MDMA / Coke: Lowers seizure threshold, anxiety and panic risk.
- + Alcohol: Blackouts, impulsivity, seizures more likely.
🛑 Benzos + Depressants
- + Opiates: Breathing stops. People die in their sleep.
- + Alcohol: Common, still deadly. Respiratory depression.
- + K / GHB: Memory loss, vomit risk, loss of control.
🌿 ADHD Meds + Stimulants
- + MDMA / Coke / Meth: Overheating, heart stress, stroke potential.
- + Alcohol: Blackouts, impaired judgment, risk-taking.
- + Psychedelics: Heightened confusion, intensity.
🧬 Antipsychotics + Psychedelics
(Seroquel, Abilify, Risperdal, Latuda)
- May block trips but cause rebound panic/psychosis.
- Redosing on MDMA can cause serotonin overload.
🌀 Mood Stabilizers + Psychedelics
(Lamictal, Lithium)
- Lamictal = flat or dysphoric trips.
- Lithium = 🚫 Seizures, erratic reactions, even death.
😴 Sleep Meds + Downers
- + Alcohol or Benzos: Risk of blackout, breathing issues.
- + K or GHB: Dangerous sedation and vomit risk.
⚠️ Gabapentin + Alcohol or Opiates
- Enhances sedation and euphoria → OD risk increases fast.
🍊 Grapefruit + Everything
- Blocks liver enzyme CYP3A4 → drugs build up in your system.
- Risk: Serotonin syndrome, overdose, seizures.
🎛️ Interaction Checker
Select two substances or meds to see the risk: