Polydrug Interaction Checker ⚡💊💀🌈
Mobile-first, harm-reduction focused. Pick up to three substances and see risks & tips. Matrix is downloadable + shareable.
Tip: drag left/right to explore the grid on mobile.
💡 Harm Reduction Tips (quick)
- Test what you can. Start low, go slow. Space redoses.
- Never stack depressants (alcohol, benzos, GHB, opioids) — biggest driver of fatal ODs.
- Heat + stimulants = risk. Cool environment, electrolyte sips, rest breaks.
- Carry naloxone if opioids could be around. Don’t use alone. Recovery position if someone is out.
- On Rx meds? Avoid chasing “muted” effects by redosing — risk goes up even if euphoria doesn’t.
Combo Categories
💊 Depressant × Depressant benzodiazepines, alcohol, GHB, opioids, trazodone, gabapentin
Risk: 💀 — synergistic respiratory depression, blackouts, aspiration.
- Keep people awake & breathing; recovery position if unresponsive.
- Naloxone reverses opioids (not benzos/GHB); still call EMS.
⚡ Stimulant × Stimulant MDMA, cocaine, ADHD meds, bupropion
Risk: 💊→💀 — hypertension, hyperthermia, arrhythmia, panic.
- Avoid stacking; cool down, hydrate, don’t chase muted highs.
⚡ Stimulant × Depressant e.g., cocaine+alcohol, MDMA+GHB
Risk: 💊 — masking sedation, dehydration, liver stress (cocaethylene with alcohol+cocaine).
- Don’t redose to “even it out”. Watch breathing and heat load.
🌈/⚡ Psychedelics with Cannabis
Can potentiate intensity/anxiety. Delay THC until past peak; micro-puffs if at all.
⚡ Dissociative × Depressant ketamine/nitrous + alcohol/benzos/GHB
Hypoxia/airway risk + amnesia. Sit down, supervised, fresh air breaks.