Harm Reduction & Community Safety - Empowering informed decisions through education and support
Polydrug Interaction Checker ⚡💊💀🌈
Mobile-first, harm-reduction focused tool to check drug combination risks. Pick up to three substances and see detailed safety information. Matrix is downloadable + shareable.
Quick Check
🌈 Low concern⚡ Caution💊 Strong caution💀 Dangerous
Results will appear here
We'll show A+B, A+C, B+C and a combined A+B+C overview with detailed harm-reduction pointers.
Matrix Risk Key
Understanding the Risk Levels
🌈Low Risk (🌈)
Minimal interaction concerns - These substances typically have minimal negative interactions when used together. However, individual responses can vary based on dosage, tolerance, and personal health factors.
Harm Reduction Tips: Start with lower doses than you would take individually, stay hydrated, and have a sober friend present if trying this combination for the first time.
⚡Caution (⚡)
Moderate interaction concerns - These combinations may increase side effects or intensify experiences beyond comfortable levels. Requires careful dosing and monitoring.
Harm Reduction Tips: Use significantly lower doses than you would take individually, wait longer between doses to assess effects, and avoid operating vehicles or machinery.
💊Strong Caution (💊)
Significant interaction risk - These substances have known pharmacological interactions that can significantly increase risks. Should be approached with extreme caution.
Specific Risks: Potential for serotonin syndrome, respiratory depression, cardiovascular stress, or unpredictable psychological effects.
Harm Reduction Tips: Avoid this combination if possible. If combining, use minimal doses and have medical supervision available. Do not use alone.
💀Dangerous (💀)
High risk of severe harm or death - These combinations create a high risk of fatal overdose, severe medical complications, or permanent harm. Among the most dangerous drug combinations known.
Specific Life-Threatening Risks: Profound respiratory depression, cardiac arrest, seizure risk, extreme hyperthermia, or coma.
CRITICAL SAFETY INFORMATION: DO NOT COMBINE THESE SUBSTANCES. If accidental exposure occurs, call emergency services immediately.
Swipe left/right to explore the full matrix
Interaction Matrix
Harm Reduction Tips (quick)
Test what you can. Start low, go slow. Space redoses.
Never stack depressants (alcohol, benzos, GHB, opioids) — biggest driver of fatal ODs.