PLURderapolis

🧠 Polydrug Risks

Ravers don’t always stick to one thing. And that’s real. But mixing substances can make effects way less predictable and way more dangerous. Here’s what you need to know before you mix.

⚑ Stimulant + Stimulant

Examples: MDMA + Cocaine, Amphetamine + MDA

Risks: Heart attack, seizures, psychosis, serotonin syndrome, overheating.

πŸ’€ Depressant + Depressant

Examples: Alcohol + Benzos, GHB + Oxycodone

Risks: Respiratory arrest, coma, blackouts, death in sleep.

⚠️ Stimulant + Depressant

Examples: Cocaine + Alcohol, MDMA + GHB

Risks: Mixed signals to your body = dehydration, liver stress, fatal crash.

🌈 Stimulant + Psychedelic

Examples: LSD + MDMA (candyflipping)

Risks: Sensory overload, panic attacks, serotonin syndrome.

πŸŒͺ️ Depressant + Psychedelic

Examples: Benzos + LSD, Alcohol + Shrooms

Risks: Amnesia, suppressed breathing, unpredictable trips.

🧊 Ketamine Combos

Examples: K + Alcohol, K + Stimulants

Risks: Respiratory suppression, blackouts, urinary damage, overdose.

☠️ Opioid + Depressants

Examples: Heroin + Benzos, Fentanyl + Alcohol

Risks: Extremely high overdose risk. One of the most lethal combos.

🧬 Cocaine + Alcohol

Creates: Cocaethylene (more toxic than coke or alcohol alone)

Risks: Seizures, heart strain, liver toxicity.

πŸ“Š Combo Risk Matrix

Tap or hover for more info. Legend: 🟒 Low Risk | 🟑 Moderate | πŸ”΄ Caution | ❌ Unsafe | ☠️ Deadly

πŸ“Š Combo Risk Matrix

Tap or hover for more info. 🟒 Low β€’ 🟑 Moderate β€’ πŸ”΄ Caution β€’ ❌ Unsafe β€’ ☠️ Deadly

↓ / β†’CannabisKetamineMDMACocaineAlcohol GHB / OpioidsBenzosSSRIsSNRIsADHD MedsWellbutrinTrazodoneGabapentin
Cannabis-πŸŸ‘πŸ”΄πŸ”΄πŸ”΄πŸ”΄πŸ”΄πŸŸ‘πŸŸ‘πŸŸ’πŸŸ’πŸŸ’πŸŸ’
Ketamine🟑-βŒβŒβŒβŒπŸŸ‘πŸŸ‘πŸŸ‘πŸ”΄πŸŸ‘πŸŸ‘
MDMAπŸ”΄βŒ-πŸ”΄πŸ”΄βŒπŸ”΄πŸ”΄βŒβŒβŒπŸ”΄
CocaineπŸ”΄βŒπŸ”΄-πŸ”΄βŒπŸ”΄πŸ”΄βŒβŒπŸ”΄πŸ”΄
AlcoholπŸ”΄βŒπŸ”΄πŸ”΄-❌☠️⚠️⚠️⚠️❌❌
GHB / OpioidsπŸ”΄βŒβŒβŒβ˜ οΈ-☠️⚠️⚠️⚠️⚠️⚠️
BenzosπŸ”΄πŸŸ‘πŸ”΄πŸ”΄β˜ οΈβ˜ οΈ-⚠️⚠️⚠️⚠️⚠️
SSRIsπŸŸ‘πŸŸ‘πŸ”΄πŸ”΄βš οΈβš οΈβš οΈ-⚠️⚠️⚠️⚠️
SNRIs🟑🟑❌❌⚠️⚠️⚠️⚠️-⚠️⚠️⚠️
ADHD Meds🟒🟑❌❌⚠️⚠️⚠️⚠️⚠️-🟑🟑
WellbutrinπŸŸ’πŸŸ‘βŒπŸ”΄βŒβŒβš οΈβš οΈβš οΈπŸŸ‘-🟑
TrazodoneπŸŸ’πŸŸ‘βŒπŸ”΄βŒβŒβš οΈβš οΈβš οΈπŸŸ‘πŸŸ‘-
GabapentinπŸŸ’πŸŸ‘πŸ”΄πŸ”΄βŒβŒβš οΈβš οΈβš οΈπŸŸ‘πŸŸ‘-

πŸŽ›οΈ Interaction Checker

Select two substances to see if the combo is chill or sketch:

SourcesLast reviewed: October 2026.▾

This checker is a general harm reduction reference. Its risk ratings are consistent with the established combination references below:

This page is for education and harm reduction, not medical advice. In any emergency, call 911.